Nopes are giant Frostbite Spiders that mainly appear in A Skyrim Tale.
These fiends are called "Nopes" for a reason. Vahl (and Venturian) hate them and is a natural enemy of the arachnids. Instead of fighting off Nopes, Vahl usually flees away from them. Nopes mainly spawn in groups and team up on their target, like a wolf pack would.